Zero Stigma. Zero Deaths.


An Initiative to End the Opioid Epidemic

RIZE Massachusetts is an independent nonprofit foundation working to end the opioid epidemic in Massachusetts and reduce its devastating impact on people, communities, and our economy.

By tapping the commitment and resources of the private sector, we make informed investments in innovative and comprehensive evidence-based treatments that can be scaled, expedited, and made accessible to people suffering from opioid use disorder across the Commonwealth.

We forge partnerships between the business community, the health care sector, research institutions, and community leaders to disrupt the status quo on prevention and treatment of opioid use disorder, raise awareness that it is a chronic disease, and reduce stigma that impedes recovery.

What We Fund

Our strategic framework guides us in investing in the best solutions and brightest minds to end the opioid epidemic in Massachusetts and reduce its impact on individuals, families, communities, and our economy. In all our work, we have the following objectives: Embed learning and evaluation into all strategies to improve results and build evidence for sustainable, scalable approaches; reduce stigma and increase understanding of opioid use disorder as a chronic disease; and, convene, support, and partner with other key players to facilitate a coordinated approach to the opioid crisis.

Human Impact

We engage in solutions that will reduce the impact on the economy, families, and communities.


We invest in comprehensive, compassionate, and sustainable approaches to prevention, harm reduction, treatment, and recovery.


We commission and support research and evaluation that expands the evidence base and informs policy.

Partner With Us

To achieve our goals, RIZE issues grants that support evidence-based, evidence-informed, or evidence-generating initiatives designed to reduce opioid overdose and addiction, with a specific focus on the key role that health care systems can play in providing prevention, treatment, and recovery support services for substance use disorders; and recent developments that are leading to improved integration of opioid use disorder care with the rest of medicine.

RIZE is investing in meaningful solutions and employing broad perspectives to end the opioid epidemic in Massachusetts. When you donate to RIZE, you become an investor in our growing fund, which amplifies the power and reach of your contribution many times over, helping thousands of people and families across Massachusetts.

With your help, there is hope.